Indicator Explainer
SMAD4 Gene
This gene plays a role in signal transduction and transcriptional activation. It is also involved in suppression of angiogenesis.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C18258. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-19. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — SMAD4 Gene (C18258)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C18258. NCI definition, reproduced without modification under CC BY 4.0.
- Association of SMAD4 gene polymorphisms with human papillomavirus infection and risk of cervical cancer: a case-control study. — BMC Cancer, 2026-01-14 (PMID 41530702; literature)
- Prognostic role and clinicopathological features of SMAD4 gene mutation in pancreatic cancer: a systematic review and meta-analysis. — Cancer Treat Res Commun, 2026-01-02 (PMID 41576526; literature)
- Clinicopathological characteristics of SMAD4 gene expressions in colorectal cancer patients. — Cell Mol Biol (Noisy-le-grand), 2024-10-08 (PMID 39380261; literature)
- Determination of the frequency and distribution of APC, PIK3CA, and SMAD4 gene mutations in Ugandan patients with colorectal cancer. — BMC Cancer, 2024-09-30 (PMID 39350061; literature)