Indicator Explainer
NOTCH1 Gene
This gene is involved in intercellular signal transduction that plays a key role in development.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C24636. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-19. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — NOTCH1 Gene (C24636)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C24636. NCI definition, reproduced without modification under CC BY 4.0.
- NOTCH1 gene signaling pathway in the development and progression of carcinomas: an integrative review in cellular and molecular contexts. — Cell Mol Biol (Noisy-le-grand), 2026-04-30 (PMID 42545144; literature)
- Notch1 gene promoter methylation promotes phenotypic transformation and functional alteration of VSMCs to regulate acute type A aortic dissection. — Biochim Biophys Acta Gen Subj, 2026-02-12 (PMID 41690418; literature)
- A noncoding mutation in the NOTCH1 gene initiates oncogenic NOTCH signaling via wild-type NICD stabilization in CLL. — Blood, 2025-10-01 (PMID 40638689; literature)
- Single nucleotide polymorphism of Notch1 gene rs3124599 allele is associated with the severity of CVA6-related HFMD in the Chinese Han population. — BMC Infect Dis, 2024-07-29 (PMID 39075371; literature)