Indicator Explainer
Leptin
Leptin (167 aa, ~16 kDa) is encoded by the human LEP gene. This protein is secreted by adipocytes and plays a role in the regulation of both appetite and body fat stores.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C46081. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Leptin (C46081)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C46081. NCI definition, reproduced without modification under CC BY 4.0.
- Impact of setmelanotide on metabolic syndrome risk in patients with proopiomelanocortin or leptin receptor deficiencies. — J Clin Endocrinol Metab, 2026-10-19 (PMID 42895739; literature)
- Leptin promotes obesity‑related osteoarthritis progression via CD44/JAK2/STAT3 axis‑mediated chondrocyte apoptosis. — Mol Med Rep, 2026-10-16 (PMID 42885301; literature)
- Leptin Neutralization Attenuates Inflammaging in Endothelial and Immune Cell Models. — MedComm (2020), 2026-10-23 (PMID 42921584; literature)
- AAV-mediated delivery of leptin but not adiponectin improves metabolic health in a pre-clinical mouse model of congenital generalised lipodystrophy. — Gene Ther, 2026-10-23 (PMID 42919845; literature)
- Temporal organization of leptin signaling reveals distinct regulatory roles for STAT3 and ETV6. — J Mol Endocrinol, 2026-10-21 (PMID 42908474; literature)
- One-step fluorescence immunochromatographic assay for quantitative detection of adiponectin and leptin. — Anal Methods, 2026-10-15 (PMID 42713905; literature)