Indicator Explainer
Cystatin-C
Cystatin-C (146 aa, ~16 kDa) is encoded by the human CST3 gene. This protein is involved in the inhibition of cysteine proteinases.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C88359. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-19. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Cystatin-C (C88359)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C88359. NCI definition, reproduced without modification under CC BY 4.0.
- Utilization of serum cystatin C for early detection of chronic kidney disease in Type 2 diabetes mellitus and hypertension: A systematic review. — Diabetes Res Clin Pract, 2026-10-09 (PMID 42854921; literature)
- Prediction of Severe Acute Kidney Injury by Positive Renal Angina Index and Cystatin C in Children with Septic Shock: A Diagnostic Accuracy Study. — Indian Pediatr, 2026-10-09 (PMID 42853503; literature)
- Cancer Hacks Neurodegeneration: Cystatin-C as a Bridge for Microglial Amyloid Clearance via TREM2. — Research (Wash D C), 2026-10-14 (PMID 42876854; literature)
- Cystatin C and its Role in the Neuro-Glial-Vascular Unit: Implications for Cerebrovascular Diseases and Neurodegeneration. — Neurosci Bull, 2026-10-12 (PMID 42864511; literature)
- Association between multimorbidity and discordance between creatinine- and cystatin C-based eGFR. — Nephrol Dial Transplant, 2026-10-10 (PMID 42858001; literature)
- Cystatin C Based eGFR Identifies Clinically Significant Acute Kidney Injury Missed by Serum Creatinine in Pediatric Transplant-Associated Thrombotic Microangiopathy. — Transplant Cell Ther, 2026-10-08 (PMID 42849880; literature)
- Creatinine and cystatin C disagree on GFR category in half of kidney graft recipients. — J Nephrol, 2026-10-29 (PMID 42952414; literature)
- The pre-transplant cystatin C-to-serum creatinine ratio is associated with key clinical outcomes following liver transplantation. — Liver Transpl, 2026-10-23 (PMID 42912645; literature)