Indicator Explainer
Biotin
Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid. Growth factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tissue is higher than that of normal tissue.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C309. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Biotin (C309)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C309. NCI definition, reproduced without modification under CC BY 4.0.
- Functional characterization of compound heterozygous HLCS variants reveals exon skipping and impaired biotin responsiveness in holocarboxylase synthetase deficiency. — Clin Chim Acta, 2026-10-18 (PMID 42893714; literature)
- The malonyl-CoA synthetase ACSF3 is required for metabolic editing downstream of biotin carboxylation. — J Biol Chem, 2026-10-14 (PMID 42874924; literature)
- Dietary biotin supplementation modulates immune and antioxidant-related responses in the sea cucumber Apostichopus japonicus exposed to Vibrio splendidus. — Dev Comp Immunol, 2026-10-22 (PMID 42913988; literature)
- Biotin-dependent carboxylases and related disorders: Comparative mechanisms and therapeutic advances. — Mol Genet Metab, 2026-10-18 (PMID 42913226; literature)