Glossary Term
Variant Allele Frequency
PCR TermsEN
Definition
The relative rate of occurrence of a specific variant allele compared to the total number of alleles at that locus in the sample. This measurement may be reported as a ratio or percentage.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C154665. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
VAFVariant Allele Frequency
References
- NCI Thesaurus 26.09d — Variant Allele Frequency (C154665)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C154665. NCI definition, reproduced without modification under CC BY 4.0.
- Reconsidering the incremental prognostic value of variant allele frequency-based stratification beyond European LeukemiaNet 2022 in acute myeloid leukemia. — Oncologist, 2026-10-01 (PMID 42865009; literature)
- Prognostic impact of variant allele frequency in intensively treated patients with NPM1-mutated AML: a PETHEMA study. — Blood, 2026-10-01 (PMID 42258402; literature)