Glossary Term
Homologous Recombination
Definition
The process of exchange of genetic material between autonomous replicons, which depends on regions of extensive sequence homology between the participating DNA strands. This process involves double-strand breakage of one participant, resection of the break, and strand invasion, followed by formation, displacement and resolution of the Holliday junction. This process is involved in repairing broken DNA and creating combinations of genes that may be unique from the parent duplexes. Disruptions in this process can result in inviability, premature aging and predisposition to cancers and degenerative diseases.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C18144. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
References
- NCI Thesaurus 26.09d — Homologous Recombination (C18144)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C18144. NCI definition, reproduced without modification under CC BY 4.0.
- Exploring patient and clinician perspectives for homologous recombination deficient (HRD) biomarker testing to guide precision medicine for advanced ovarian cancer treatment: A qualitative study. — Patient Educ Couns, 2026-10-10 (PMID 42880199; literature)
- HRDPath: an explainable multi-model deep learning architecture for predicting homologous recombination deficiency from histopathology images. — Nat Commun, 2026-10-21 (PMID 42907492; literature)
- Corrigendum to "Whole-exome sequencing provides assessment of homologous recombination deficiency for identification of PARPi-responsive ovarian tumors" [Gynecol. Oncol. 197 (2025) 139-145]. — Gynecol Oncol, 2026-10-21 (PMID 42906228; literature)
- A non-allelic homologous recombination-induced inversion in intron 22 of the F8 gene is causative for haemophilia A in a Weimaraner male dog. — PLoS One, 2026-10-26 (PMID 42932266; literature)
- DTX3 Suppresses the NPM3-RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance. — Adv Sci (Weinh), 2026-10-29 (PMID 42958702; literature)
- Targeting G2/M checkpoint vulnerability in homologous recombination-proficient tumors: lessons from ovarian cancer models. — Cell Cycle, 2026-10-27 (PMID 42947311; literature)