Indicator Explainer
High-risk HPV
Group of HPV genotypes associated with higher risk of cervical disease.
Read this first
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Tested during cervical screening triage, often together with cytology.
Reading results
Results depend on the assay’s genotype panel and the lab’s triage algorithm; there is no single universal normal value.
Questions to ask a professional
- Which genotypes does my test cover?
- What follow-up does my result require?
Also Known As
hrHPV
References
- The natural history of human papillomavirus infection. — Best practice & research. Clinical obstetrics & gynaecology, 2018 (PMID doi: 10.1016/j.bpobgyn.2017.08.015)
- Human papillomavirus (HPV): making the case for 'Immunisation for All'. — Oral diseases, 2017 (PMID doi: 10.1111/odi.12562)
- Micronucleus cytome assay reveals genomic instability in premalignant cervical lesions among high-risk HPV-positive women. — Biotech Histochem, 2026-10-09 (PMID 42852509; literature)
- Comparison of Colorimetric LAMP and PCR for High-risk HPV Detection: Implications for Cervical Cancer Screening. — J Low Genit Tract Dis, 2026-10-01 (PMID 42565594; literature)
- Extended HPV Genotyping for Risk Stratification in Cervical Screening: A Population-based Study. — J Low Genit Tract Dis, 2026-10-01 (PMID 42565593; literature)
- NF-κB signaling in persistent high-risk cervical HPV infection: Clinical evidence, molecular mechanisms, and translational therapeutic opportunities. — Int Rev Immunol, 2026-09-28 (PMID 42804243; literature)
- Multimodality detection of early relapse in radically treated high-risk HPV-negative head and neck squamous cell carcinoma: study protocol for a prospective multicentre UK cohort study (HERD). — BMJ Open, 2026-09-24 (PMID 42785937; literature)
- HPV-Associated Oropharyngeal Squamous Cell Carcinoma and Persistent Oral High-Risk HPV Detection: A Narrative Review of Longitudinal Assessment, Diagnostic Evaluation, and Surveillance. — Int J Mol Sci, 2026-09-21 (PMID 42794837; literature)
- Beyond HPV16/18: genotype distribution of high-risk HPV and cycle threshold values in cervical carcinogenesis spectrum. — Ann Med, 2026-10-15 (PMID 42878366; literature)
- Cytology, High-Risk HPV Genotyping, and Histology in Cervical Pathology: A Retrospective Cohort Study. — Diagnostics (Basel), 2026-10-02 (PMID 42882358; literature)
- Contemporary High-risk Human Papillomavirus Genotype Distribution and Associated Cytologic Findings Using Extended Human Papillomavirus Genotyping. — J Low Genit Tract Dis, 2026-10-23 (PMID 42912443; literature)
- Analytical performance and clinical usability of a low-cost vaginal swab for sensitive detection of high-risk human papillomavirus. — Gates Open Res, 2026-10-15 (PMID 42892759; literature)