GuideDiagnostic Laboratory Methods

Selected Reaction Monitoring

A method for collecting tandem mass spectrometry data where an ion of a particular mass is selected in the first stage and a fragmented ion product is selected in the second mass spectrometer stage for detection. Selected reaction monitoring (SRM)-based experiments are generally performed in a triple quadrupole (QqQ) mass spectrometer.

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Updated
2026-10-20
Author
National Cancer Institute (source definition)
Reviewer
Automated source check (NCI definition)

Review and references

Author

National Cancer Institute (source definition)

Reviewer

Automated source check (NCI definition)

Published

2026-10-20

Updated

2026-10-20

Disclaimer

professional use

What it is

A method for collecting tandem mass spectrometry data where an ion of a particular mass is selected in the first stage and a fragmented ion product is selected in the second mass spectrometer stage for detection. Selected reaction monitoring (SRM)-based experiments are generally performed in a triple quadrupole (QqQ) mass spectrometer.

Source: National Cancer Institute, NCI Thesaurus 26.09d, C161787. NCI definition, reproduced without modification under CC BY 4.0.

Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.

Compliance note

Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.