Indicators
A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05)
Indicators
This gene plays a role in chromatin remodeling and transcriptional regulation.
Indicators
An abnormality that refers to mutation of factor V Leiden, which is a variant of human factor V. It results in thrombophilia, deep vein thrombosis, and a slightly increased risk of miscarriage.
Indicators
This gene may be involved in the mediation of DNA repair.
Indicators
This gene may play a role in DNA cross-link repair.
Indicators
This gene is involved in the regulation of meiosis, DNA repair and the cell cycle.
Indicators
This gene plays a role in the regulation of both DNA repair and protein localization.
Indicators
This gene may be involved in the regulation of DNA repair.
Indicators
This gene is involved in the maintenance of genomic integrity and nuclear signal transduction. Allelic variants of the gene are involved in Fanconi syndrome.
Indicators
This gene is involved in the mediation of protein ubiquitination.
Indicators
This gene is involved in ubiquitin-dependent proteolysis and regulation of the G1-S cell cycle checkpoint.
Indicators
Blood in the feces that is not visibly apparent.
