Indicator Explainer
MTHFR Gene
This gene is involved in folate metabolism and methionine biosynthesis.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C18500. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-18. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — MTHFR Gene (C18500)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C18500. NCI definition, reproduced without modification under CC BY 4.0.
- Global DNA methylation and MTHFR gene polymorphism status of ghanaians with early-onset intracerebral hemorrhage: implications for future interventions. — Equity Neurosci, 2026-09-01 (PMID 42305577; literature)
- Association Between MTHFR Gene Polymorphisms and Subclinical Hypothyroidism in Early Pregnancy: A Retrospective Case-Control Study. — Int J Womens Health, 2026-06-18 (PMID 42338702; literature)
- MTHFR gene polymorphisms and their biochemical associations with serum vitamin D and IL-17 in ulcerative colitis. — J Med Biochem, 2026-05-01 (PMID 42781488; literature)
- Allelic and Genotypic Distribution of rs1801133 in the Methylene Tetrahydrofolate Reductase (MTHFR) Gene Among Family Trios Affected by Nonsyndromic Cleft Lip and Palate. — Cureus, 2026-03-29 (PMID 42058361; literature)