Glossary Term

Somatic Variation

PCR TermsEN

Definition

Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though they will be transmitted during any mitosis within the individual. Somatic mutations may contribute to a broad variety of pathologies including cancer.

Extended Notes

Source: National Cancer Institute, NCI Thesaurus 26.09d, C18060. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.

Also Known As

Somatic MutationSomatic Mutation AbnormalitySomatic VariantSomatic Variation

References

NCI Thesaurus 26.09d — Somatic Variation (C18060)
Source: National Cancer Institute, NCI Thesaurus 26.09d, C18060. NCI definition, reproduced without modification under CC BY 4.0.