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Human ANPEP wild-type allele is located within 15q25-q26 and is approximately 30 kb in length. This allele, which encodes aminopeptidase N protein, is involved in the modulation of peptide hydrolysis and human infection by cytomegalovirus and coronavirus.
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Appetite-regulating hormone (117 aa, ~13 kDa) is encoded by the human GHRL gene. This protein is involved in satiety, thirst and anxiety and regulating growth hormone release.
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C peptide (31 aa, ~3 kDa) is encoded by the human INS gene. This protein is involved in both signal transduction and the modulation of blood flow.
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Gastrin-releasing peptide (27 aa, ~3 kDa) is encoded by the human GRP gene. This protein is involved in hormone signaling in both the gastrointestinal and nervous systems.
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Interleukin-8 (99 aa, ~11 kDa) is encoded by the human CXCL8 gene. This protein is involved in chemotaxis and neutrophil activation.
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A peptide released when the heart is under pressure or strain; used in the workup of heart failure.
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Secretogranin-1 (677 aa, ~78 kDa) is encoded by the human CHGB gene. This protein may play a role in the synthesis of biologically active peptides.
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A branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis.
