Glossary Term
Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases.
Pcr Terms
Indicators
This gene is involved in transcriptional repression and protein degradation.
Indicators
This gene plays a role in regulation of transcription. It is involved in the control of both cell differentiation and proliferation.
Technology
A procedure that can determine the nucleotide sequence for all of the RNA transcripts in an individual.
Diagnostic Methods
Tests
The determination of cellular CD134 expression in a biological specimen.
For professionals
Indicators
This gene plays a role in hematopoietic cell proliferation and development.
Tests
The determination of the expression levels of MYCL mRNA in a biological sample.
For professionals
Tests
PCR (polymerase chain reaction) tests are a reliable and accurate way to diagnose certain infectious diseases , some types of cancer , and certain genetic changes. The tests check for small amounts of genetic material of a pathogen (disease-causing organism) or abnormal cells in a sample of your blood, saliva, mucus, or tissue. The genetic material could be:
For everyone & professionals
Indicators
This gene is involved in the regulation of cell differentiation, growth and proliferation.
Glossary Term
The complete set of RNA transcripts that are produced by the genome, under specific circumstances or in a specific cell.
Pcr Terms
