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A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04)
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This gene is involved in epigenetic control of gene expression.
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This gene plays a role in the negative regulation of transcription.
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This gene plays a role in DNA repair and regulation of transcription.
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This gene is involved in signal transduction pathways that result in cellular proliferation or differentiation. The gene has also been associated with numerous cancers.
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This gene is involved in neuronal development and plays a role in receptor tyrosine kinase signal transduction that regulates cellular proliferation and differentiation.
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This gene is involved in nucleotide excision repair and corrects sensitivity to UV radiation and defective nucleotide excision repair in xeroderma pigmentosum cells of complementation group D.
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This gene plays a regulatory role in transcription, cellular maintenance and hematopoiesis.
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This gene plays a regulatory role in transcription and in matrix metalloproteinase activity.
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A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05)
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This gene plays a role in chromatin remodeling and transcriptional regulation.
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This gene may be involved in the mediation of DNA repair.
