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The determination of the ratio of abnormal kappa positive plasma cells to abnormal lambda positive plasma cells present in a sample. The measurement may be expressed as a ratio or percentage.
Indicators
This gene plays a role in transcriptional regulation and in NF-kappa B signal transduction.
Tests
A free light chains test measures the level of free light chains in your blood. Light chains are proteins made by plasma cells, a type of white blood cell. Light chains usually link up with other proteins called heavy chains. Together, the light and heavy chains make immunoglobulins, also called antibodies. Antibodies are proteins that your immune system makes to fight germs such as viruses and bacteria .
Indicators
This gene is involved in protein phosphorylation.
Indicators
Immunoglobulin Light Chain Kappa is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains. Ig kappa light chains contain a variable and a constant region. Kappa light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. Diversity in the kappa light chain V region arises during differentiation of an activated (kappa-type) antibody-producing B-cell from variable recombination of kappa V genes with kappa J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM and NCI)
Tests
The determination of the ratio of kappa positive plasma cells to lambda positive plasma cells present in a sample. The measurement may be expressed as a ratio or percentage.
Article
Research record from Clin Lab, 2026-09-11. PMID 42726200.