Indicators
A protein complex composed of 18 complement component 1q (C1q) subcomponent chains: six C1qA, six C1qB and six C1qC. The C1q complex is part of the complement component C1 complex (C1 complex) and undergoes confirmational rearrangement following binding of pentraxins or antigen-antibody complexes that include either immunoglobulin M (IgM) or several IgG molecules. These confirmational changes activate the C1r chains of the C1 complex, which, in turn, cleaves C1s chains of the C1 complex. Following C1s cleavage, the C1 complex can proteolytically activate C2 and C4 and promotes formation of C3-convertase, which cleaves C3 and activates the classical complement pathway.
Indicators
Complement component C6 (934 aa, ~105 kDa) is encoded by the human C6 gene. This protein is involved in complement-mediated host defense responses.
Indicators
Complement component C7 (843 aa, ~94 kDa) is encoded by the human C7 gene. This protein is involved in insertion of the membrane attack complex in lipid bilayers.
Indicators
A heterotrimeric protein complex composed of complement component 8 (C8) chains alpha, beta and gamma. The alpha and gamma chains form a disulfide-linked dimer that is noncovalently associated with the beta chain. C8 inserts itself into target cell membranes following formation of the C5b-6-7 complex and then recruits 10-16 molecules of C9 to complete the formation of the membrane attack complex.
Indicators
Complement component C9 (559 aa, ~63 kDa) is encoded by the human C9 gene. This protein plays a role in complement-mediated bacterial cell lysis.
Tests
A complete blood count, or CBC, is a group of blood tests that measure the number and size of the different cells in your blood. A CBC measures:
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Tests
A comprehensive metabolic panel (CMP) is a routine blood test that measures 14 different substances in a sample of your blood. It provides important information about your metabolism (how your body uses food and energy) and the balance of certain chemicals in your body.
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Glossary Term
A range of values for a parameter that may contain the parameter and the degree of confidence that it is in fact there.
Performance Metrics
Glossary Term
A sequence pattern derived from the alignment of multiple sequences that represents the nucleotide or amino acid most likely to occur at each position in a sequence.
Pcr Terms
Glossary Term
The presence of any substance or organism that makes a preparation impure.
Performance Metrics
Glossary Term
Variation in the number of copies of a particular sequence within the genetic material of an individual. Large-scale copy number polymorphisms are common and widely distributed in the human genome.
Pcr Terms
Tests
Cord blood is the blood left in the umbilical cord after a baby is born. The umbilical cord connects a mother to her unborn baby during pregnancy . It contains blood vessels that bring nourishment to the baby and remove waste products.
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