Indicators
SETBP1 Gene
This gene may be involved in the modulation of protein SET activity.
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Indicators
This gene may be involved in the modulation of protein SET activity.
Indicators
This gene is involved in epigenetic control of gene expression through histone methylation.
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A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)
Indicators
This gene plays a role in chromatin remodeling, cell cycle control and regulation of transcription.
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This gene plays a role in chromatin remodeling and regulation of transcription.
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This gene is involved in chromatin remodeling and regulation of transcription.
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This gene plays a role in G protein-coupled receptor signal transduction and sonic hedgehog pathway activation.
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Soluble monocyte differentiation antigen CD14 is encoded by the human CD14 gene. This soluble protein may be used as a marker of monocyte activation and is derived either through cleavage that removes the glycophosphoinositol (GPI)-anchor from the membrane bound form of CD14 or as non-cleaved form secreted from the non-GPI-modified intracellular pool of CD14.
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This gene is involved in guanine nucleotide exchange.
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This gene is involved in embryonic development and in the determination of cell fate.
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This gene is involved in protein ubiquitination, which often leads to proteasomal degradation.
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A secreted antigen derived from two nearly identical cytoplasmic glycoproteins of the serpin family, serpin B3 (SCCA-1) and serpin B4 (SCCA-2). These proteins are specifically expressed in normal squamous epithelia and are present at elevated concentrations in the serum of subjects with squamous cell carcinoma and certain inflammatory and autoimmune diseases. This antigen was first described in squamous cell cervical carcinoma; it is currently used as a nonspecific tumor marker for the presence, staging and monitoring of the disease course for squamous cell carcinomas of the head and neck, cervix, esophagus, anus and lung.