Indicators
MDM4 Gene
This gene plays a role in both cell cycle arrest and the inhibition of apoptosis.
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Indicators
This gene plays a role in both cell cycle arrest and the inhibition of apoptosis.
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A product of hemoglobin produced by oxidation of the iron atom from the ferrous to the ferric state.
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An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.
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This gene is involved in transcriptional promotion in melanocytes.
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This gene plays a role in apoptosis, cell growth, differentiation and proliferation.
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This gene plays a role in hematopoietic cell proliferation and development.
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This gene plays a role in cell cycle progression and apoptosis. Cytogenetic aberrations in the gene are involved in cellular transformation and are associated with a variety of hematopoietic tumors, leukemias and lymphomas.
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This gene is involved in transcriptional regulation and is frequently amplified in small-cell lung cancer.
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This gene is involved in transcriptional regulation and amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
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This gene plays a regulatory role in muscle contraction and the required ATP hydrolysis.
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This gene plays a role in DNA repair and cell cycle checkpoints.
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This gene plays a role in signal transduction and cytoskeletal remodeling.