Indicators
A protein complex composed of 18 complement component 1q (C1q) subcomponent chains: six C1qA, six C1qB and six C1qC. The C1q complex is part of the complement component C1 complex (C1 complex) and undergoes confirmational rearrangement following binding of pentraxins or antigen-antibody complexes that include either immunoglobulin M (IgM) or several IgG molecules. These confirmational changes activate the C1r chains of the C1 complex, which, in turn, cleaves C1s chains of the C1 complex. Following C1s cleavage, the C1 complex can proteolytically activate C2 and C4 and promotes formation of C3-convertase, which cleaves C3 and activates the classical complement pathway.
Indicators
Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length protein is a precursor that is secreted as a trimeric molecule containing an alpha, beta and gamma chain. When the complement cascade is initiated, the protein is cleaved. This proteolysis releases both the alpha chain, C4 anaphylatoxin, which stimulates inflammation, and a dimer of the beta and gamma chains, which mediates the interaction between the antigen-antibody complex and other complement components.
Tests
A complete blood count, or CBC, is a group of blood tests that measure the number and size of the different cells in your blood. A CBC measures:
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Tests
A comprehensive metabolic panel (CMP) is a routine blood test that measures 14 different substances in a sample of your blood. It provides important information about your metabolism (how your body uses food and energy) and the balance of certain chemicals in your body.
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Glossary Term
A range of values for a parameter that may contain the parameter and the degree of confidence that it is in fact there.
Performance Metrics
Glossary Term
The presence of any substance or organism that makes a preparation impure.
Performance Metrics
Glossary Term
Variation in the number of copies of a particular sequence within the genetic material of an individual. Large-scale copy number polymorphisms are common and widely distributed in the human genome.
Pcr Terms
Tests
Cord blood is the blood left in the umbilical cord after a baby is born. The umbilical cord connects a mother to her unborn baby during pregnancy . It contains blood vessels that bring nourishment to the baby and remove waste products.
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Glossary Term
The degree to which two or more quantities or events are linearly associated, a statistical relation between two or more variables such that systematic changes in the value of one variable are accompanied by systematic changes in the others.
Performance Metrics
Tests
A cortisol test measures the level of cortisol in your blood, urine (pee), or saliva (spit). Cortisol is a hormone made by your adrenal glands, two small glands that sit above your kidneys. Hormones are chemical messengers in your bloodstream that control the actions of certain cells or organs. Cortisol affects almost every organ and tissue in your body. It helps your body:
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Tests
This test measures the amount of creatine kinase (CK) in a sample of your blood. CK is also called creatine phosphokinase (CPK).
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Indicators
An enzyme complex that can reversibly convert ATP and creatine to phosphocreatine and ADP. Cytosolic creatine kinases are comprised of homodimers or heterodimers of creatine kinase B-type protein and creatine kinase M-type protein. Mitochondrial creatine kinases are octomers comprised of either four homodimers of creatine kinase U-type, mitochondrial protein or four creatine kinase S-type, mitochondrial protein homodimers.
