Indicators
A protein complex composed of 18 complement component 1q (C1q) subcomponent chains: six C1qA, six C1qB and six C1qC. The C1q complex is part of the complement component C1 complex (C1 complex) and undergoes confirmational rearrangement following binding of pentraxins or antigen-antibody complexes that include either immunoglobulin M (IgM) or several IgG molecules. These confirmational changes activate the C1r chains of the C1 complex, which, in turn, cleaves C1s chains of the C1 complex. Following C1s cleavage, the C1 complex can proteolytically activate C2 and C4 and promotes formation of C3-convertase, which cleaves C3 and activates the classical complement pathway.
Indicators
Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length protein is a precursor that is secreted as a trimeric molecule containing an alpha, beta and gamma chain. When the complement cascade is initiated, the protein is cleaved. This proteolysis releases both the alpha chain, C4 anaphylatoxin, which stimulates inflammation, and a dimer of the beta and gamma chains, which mediates the interaction between the antigen-antibody complex and other complement components.
Glossary Term
Problem associated with the degree to which an antibody or antigen participates in cross reactions.
Performance Metrics
Tests
The determination of the cross-reactive antidrug binding IgG and/or IgM antibody in a biospecimen.
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Tests
The determination of the cross-reactive binding antidrug antibody in a biological sample.
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Tests
The determination of the cross-reactive antidrug binding IgA antibody in a biospecimen.
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Tests
The determination of the amount of cross-reactive binding antidrug IgG antibody present in a sample.
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Tests
The determination of the cross-reactive antidrug binding IgG3 antibody in a biospecimen.
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Tests
CSF stands for cerebrospinal fluid. IgG stands for immunoglobulin G. It is a type of antibody. Antibodies are proteins that your immune system makes to fight germs . A CSF IgG index measures the levels of IgG in your cerebrospinal fluid.
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Tests
The determination of the amount of cyclic citrullinated peptide antibody present in a sample.
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Tests
The determination of the amount of cyclic citrullinated peptide IgG antibody present in a sample.
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Tests
Cytomegalovirus (CMV) tests check for signs of CMV in your blood, sputum, or other body fluids. CMV is a virus in the herpes family. Other types of herpes viruses include the viruses that cause chickenpox and mononucleosis (mono) .
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