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A cancer-specific antigen associated with both tumors and the developing fetus. The main use of this antigen is as a tumor marker, especially with respect to intestinal cancers. Production of the antigen ceases shortly before birth, but may reappear in people who develop certain types of cancer.
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This gene plays a role in the regulation of mitotic events.
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This gene is involved in the regulation of the G1/S phase of the cell cycle.
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This gene is involved in both signal transduction and the metabolism of ADP-ribose.
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This gene plays a role in cell-cell adhesion and loss of function contributes to the progression of many carcinomas.
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This gene plays a role in the progression of the cell cycle.
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This gene plays a role in body weight homeostasis and cellular proliferation. Mutations in the gene are associated with acute myeloid leukemia.
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Ceruloplasmin (1065 aa, ~122 kDa) is encoded by the human CP gene. This protein is involved in iron homeostasis.
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This gene is involved in the negative regulation of cell growth.
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This gene plays a role in cell survival and the negative regulation of cell growth.
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A chlorine anion that forms the negatively charged part of certain salts, including sodium and hydrogen chloride salts, and is an essential electrolyte located in all body fluids responsible for maintaining acid/base balance, transmitting nerve impulses and regulating fluid in and out of cells.
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An animal sterol found in the body tissues (and blood plasma) of vertebrates. It can be found in large concentrations within the liver, spinal cord, and brain. Cholesterol is an important component of the membranes of cells, providing stability. It is the major precursor for the synthesis of vitamin D, of the various steroid hormones, including cortisol, cortisone, and aldosterone in the adrenal glands, and of the sex hormones progesterone, estrogen, and testosterone. Cholesterol also has an important role for the brain synapses as well as in the immune system. In conditions featuring elevated low density lipoproteins (LDL), cholesterol often forms plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease.
