Article
The clinical value of metagenomic next generation sequencing in the diagnosis of non-neutropenic invasive pulmonary aspergillosis.
Research record from Front Cell Infect Microbiol, 2026-04-14. PMID 42058175.
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Article
Research record from Front Cell Infect Microbiol, 2026-04-14. PMID 42058175.
Article
Research record from Cancer Treat Res Commun, 2026-04-22. PMID 42172690.
Indicators
A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation.
Indicators
An aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation.
Article
Research record from J Mol Diagn, 2026-09-11. PMID 42727688.
Indicators
This gene plays a critical role in cell cycle regulation and has tumor suppressor activity.
Tests
The determination of the amount of traditional circulating tumor cells present in a sample.
Glossary Term
The complete set of RNA transcripts that are produced by the genome, under specific circumstances or in a specific cell.
Indicators
Transforming growth factor beta-1 (390 aa, ~44 kDa) is encoded by the human TGFB1 gene. This protein is involved in cell proliferation, cell death and a large number of signal transduction pathways.
Tests
The determination of the ratio of transitional cells compared to tumor cells present in a sample. The measurement may be expressed as a ratio or percentage.
Indicators
Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction. Troponin T binds tropomyosin to the troponin complex and inhibits F-actin-myosin interactions. The troponin T gene family comprises three isoforms: slow skeletal (TNNT1), cardiac (TNNT2) and fast skeletal (TNNT3). Because it is not normally found in blood, cardiac troponin-T in serum is a sensitive indicator of myocardial cell injury.
Indicators
This gene is involved in cell cycle regulation and the loss of cellular adhesion.