Indicators
TNFAIP3 Gene
This gene may play a role in the regulation of apoptosis.
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Indicators
This gene may play a role in the regulation of apoptosis.
Indicators
An aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation.
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This gene plays a role in both transcriptional regulation and limb development.
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Transforming growth factor beta-1 (390 aa, ~44 kDa) is encoded by the human TGFB1 gene. This protein is involved in cell proliferation, cell death and a large number of signal transduction pathways.
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This gene is involved in cell cycle regulation and the loss of cellular adhesion.
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This gene plays a role in signal transduction and cell cycle control. It is involved in cell adhesion, differentiation, growth and migration.
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This gene is involved in RNA binding and pre-mRNA splicing.
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A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)
Indicators
A branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis.
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Vascular endothelial growth factor A (232 aa, ~27 kDa) is encoded by the human VEGFA gene. This protein plays a role in both cell proliferation and angiogenesis.
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This gene plays a role in regulation of transcription. It is involved in the control of both cell differentiation and proliferation.
Indicators
This gene plays a role in the regulation of nuclear export.