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Indicators
An antinuclear antibody directed against 52 or 60 kDa RNA-binding proteins in the nucleus. They can be associated with multiple autoimmune disorders, primarily Sjogren syndrome and system lupus erythematosus. Maternal anti-Ro antibody positivity can be associated with neonatal lupus.
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An antinuclear antibody directed against small nuclear ribonucleoproteins (snRNPs), that is highly specific, but has poor sensitivity for systemic lupus erythematosus (SLE). Presence of anti-Sm antibodies are associated with central nervous system, kidney, lung and cardiac involvement in SLE, but are not indicative of disease activity.
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An autoantibody that reacts with cardiolipin. Different immunoglobulin subclasses and isotypes are associated with different diseases and conditions. Some anticardiolipin antibodies prolong phospholipid dependent clotting while others are associated with spontaneous abortion.
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This gene plays a role in the transcriptional activation of androgen responsive genes.
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This gene plays a role in transcriptional regulation.
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This gene plays a role in both chromatin remodeling and transcriptional regulation.
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This gene is involved in both transcriptional regulation and chromatin remodeling.
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This gene is involved in apoptosis, DNA repair and cell cycle regulation.
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This gene is involved in cell cycle checkpoints and DNA recombination.
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This gene plays a role in the regulation of both chromatin remodeling and transcription.
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This gene is involved in signal transduction and plays a role in development.
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This gene is involved in cellular growth regulation and is purported to have tumor suppression activity.
